Comment on "A second trigeminal CGRP receptor: function and expression of the AMY1 receptor".
نویسندگان
چکیده
We read with the great interest the recent publication on a second trigeminal CGRP receptor by Walker et al. The authors convincingly present the presence of a functional noncanonical CGRP receptor (AMY1) at neuronal sites in the trigeminal system. The presence of a second CGRP receptor has been debated and although it is not yet recognized by IUPHAR, several reports have previously suggested the presence of more than one CGRP receptor. We have previously published reports on the effect of olcegepant and telcagepant in the human coronary artery. In these studies, we evaluated several concentra-
منابع مشابه
A second trigeminal CGRP receptor: function and expression of the AMY1 receptor
OBJECTIVE The trigeminovascular system plays a central role in migraine, a condition in need of new treatments. The neuropeptide, calcitonin gene-related peptide (CGRP), is proposed as causative in migraine and is the subject of intensive drug discovery efforts. This study explores the expression and functionality of two CGRP receptor candidates in the sensory trigeminal system. METHODS Recep...
متن کاملReply to comment on: A second trigeminal CGRP receptor: function and expression of the AMY1 receptor.
In their comment, Haanes et al., suggest that CGRP could act through two distinct receptors in human coronary arteries; namely the CGRP receptor (CLR/RAMP1) and the AMY1 receptor (CTR/RAMP1). 1 Although there are other possible explanations, the presence of multiple CGRP receptor subtypes could explain their elegant data. In light of the active clinical development of blocking antibodies and sm...
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CGRP, which coexists with acetylcholine in trigeminal motoneurons, could be one of the regulatory anterograde factors responsible for the enhanced expression of AChR subunits in neuromuscular junction. It has been also shown that low level of thyroid hormone plasma concentration has influence on the transitional development of muscle fibers and related motoneurons through a sever reduction in A...
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متن کاملThe effect of hypothyroidism on the trigeminal calcitonin gene-related peptide containing motoneurons: an immunohisto-chemical study in late neonatal life
CGRP, which coexists with acetylcholine in trigeminal motoneurons, could be one of the regulatory anterograde factors responsible for the enhanced expression of AChR subunits in neuromuscular junction. It has been also shown that low level of thyroid hormone plasma concentration has influence on the transitional development of muscle fibers and related motoneurons through a sever reduction in A...
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ورودعنوان ژورنال:
- Annals of clinical and translational neurology
دوره 3 4 شماره
صفحات -
تاریخ انتشار 2016